Zopiclone degradation in biological samples Characteristics and consequences in forensic toxicology

نویسنده

  • Gunnel Nilsson
چکیده

.............................................................................................................................. 1 POPULÄRVETENSKAPLIG SAMMANFATTNING............................................................. 3 LIST OF PAPERS...................................................................................................................... 5 ABBREVIATIONS.................................................................................................................... 6 INTRODUCTION...................................................................................................................... 7 Forensic toxicology ............................................................................................................ 7 Biological samples.............................................................................................................. 8 Pre-analytical conditions .................................................................................................... 8 Analytical strategies............................................................................................................ 9 Storage stability in biological samples ............................................................................. 10 Design and evaluation of stability experiments................................................................ 10 Stability investigations of drugs in biological specimens................................................. 11 Zopiclone .......................................................................................................................... 12 Pharmacodynamics .................................................................................................... 13 Pharmacokinetics ....................................................................................................... 14 Occurrence of zopiclone in forensic cases ................................................................. 15 Analytical methodology............................................................................................. 18 In vitro stability studies.............................................................................................. 18 AIMS OF THESIS ................................................................................................................... 21 Specific aims..................................................................................................................... 21 Paper I ........................................................................................................................ 21 Paper II ....................................................................................................................... 21 Paper III...................................................................................................................... 21 Paper IV ..................................................................................................................... 21 INVESTIGATIONS................................................................................................................. 23 Stability tests of zopiclone in whole blood (Paper I)........................................................ 23 Initiation ..................................................................................................................... 23 Study design............................................................................................................... 23 Influence of pre-analytical conditions on the interpretation of zopiclone (Paper II) ....... 24 Initiation ..................................................................................................................... 24 Study design............................................................................................................... 24

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Stability of zopiclone in whole blood Studies from a forensic perspective

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تاریخ انتشار 2014